https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10440 106 cfu/mL) was cultured from the sputum of 17 (15%) subjects with stable asthma and was associated with higher total cell counts, proportion and number of neutrophils, sputum IL-8 and 8-isoprostane concentrations. The role of bacteria in potentiating neutrophilic asthma warrants further investigation. Therapies such as antibiotic and antioxidant treatment may be most effective in this sub-group of patients.]]> Sat 24 Mar 2018 08:13:16 AEDT ]]> Clarithromycin targets neutrophilic airway inflammation in refractory asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4857 Sat 24 Mar 2018 07:18:49 AEDT ]]> Theophylline represses IL-8 secretion from airway smooth muscle cells independently of phosphodiesterase inhibition: novel role as a protein phosphatase 2A activator https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25564 ex vivo and in vivo models of respiratory disease. Thus, our study is the first to link theophylline with PP2A activation as a novel mechanism to control respiratory inflammation.]]> Fri 01 Apr 2022 09:21:01 AEDT ]]>